Queensdale Avenue will be closed between Upper Wentworth Street and Upper Sherman until early December.
The closure starts Wednesday; local access will be provided.
The public works department says the closure is necessary in order to complete ongoing underground servicing and road work.
Block-by-block closures of Queensdale have been taking place since early October.
The work on the central Mountain road involves water main replacement and road reconstruction from Upper Wentworth to Upper Sherman.
The first phase of construction has been implemented from Upper Wentworth to East 24th Street and is expected to be completed by early December. In the spring, work will resume with the balance expected to be completed by next summer.